Plasmin, one of the most potent and reactive serine proteases, is involved in various
physiological processes, including embryo development, thrombolysis, wound healing and …

Tumor metastasis is a complex multistep process by which cells from the primary tumor
invade tissues, move through the vasculature, settle at distant sites and eventually grow to …

A major roadblock prohibiting effective cellular immunotherapy of pancreatic ductal
adenocarcinoma (PDAC) is the lack of suitable tumor-specific antigens. To address this …

Specific cleavage of the transmembrane molecule, CUB domain-containing protein-1
(CDCP1), by plasmin-like serine proteases induces outside–in signal transduction that …

CUB domain–containing protein 1 (CDCP1) is a membrane protein that is highly expressed
in several solid cancers. We reported previously that CDCP1 regulates anoikis resistance as …

It has been proposed that CD6, an important regulator of T cells, functions by interacting with
its currently identified ligand, CD166, but studies performed during the treatment of …

Osteosarcoma (OS) is the most common primary bone malignancy. Many patients develop
relapse and metastasis after treatments, and more effective treatments are needed for …

We report the application of quantitative mass spectrometry to identify plasma membrane
proteins differentially expressed in melanoma cells with high vs. low metastatic abilities …

Involvement of Ras in cancer initiation is known, but recent evidence indicates a role in
cancer progression, including metastasis and invasion; however, the mechanism is still …

A common genetic mutation found in clear cell renal cell carcinoma (CC-RCC) is the loss of
the von Hippel-Lindau (VHL) gene, which results in stabilization of hypoxia-inducible factors …