RET signaling pathway and RET inhibitors in human cancer

AT Regua, M Najjar, HW Lo - Frontiers in Oncology, 2022 - frontiersin.org
Rearranged during transfection (RET) receptor tyrosine kinase was first identified over thirty
years ago as a novel transforming gene. Since its discovery and subsequent pathway …

Thyroid carcinoma: phenotypic features, underlying biology and potential relevance for targeting therapy

J Hu, IJ Yuan, S Mirshahidi, A Simental, SC Lee… - International journal of …, 2021 - mdpi.com
Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent
advances in biological technologies have been advancing the delineation of genetic …

Fibroblast Activation Protein-Targeted Radioligand Therapy with 177Lu-EB-FAPI for Metastatic Radioiodine-Refractory Thyroid Cancer: First-in-Human, Dose …

H Fu, J Huang, T Zhao, H Wang, Y Chen, W Xu… - Clinical Cancer …, 2023 - AACR
Purpose: Fibroblast activation protein (FAP) is a promising target for tumor treatment. In this
study, we aimed to investigate the safety and efficacy of the albumin binder-conjugated FAP …

Anlotinib in locally advanced or metastatic medullary thyroid carcinoma: a randomized, double-blind phase IIB trial

D Li, Y Chi, X Chen, M Ge, Y Zhang, Z Guo… - Clinical Cancer …, 2021 - AACR
Purpose: Medullary thyroid cancer (MTC) accounts for about 2% of all thyroid cancer, but
has a relatively poor prognosis compared with differentiated thyroid cancer. Anlotinib is a …

Molecular profiling of 50 734 Bethesda III-VI thyroid nodules by ThyroSeq v3: implications for personalized management

S Chiosea, SP Hodak, L Yip, D Abraham… - The Journal of …, 2023 - academic.oup.com
Context Comprehensive genomic analysis of thyroid nodules for multiple classes of
molecular alterations detected in a large series of fine needle aspiration (FNA) samples has …

Multikinase inhibitor treatment in thyroid cancer

OV Ancker, M Krüger, M Wehland, M Infanger… - International journal of …, 2019 - mdpi.com
Thyroid cancer is the most common endocrine malignancy. Most thyroid cancer types
respond well to conventional treatment consisting of surgery and radioactive iodine (RAI) …

Multiple endocrine neoplasia type 2: A review

JS Mathiesen, G Effraimidis, M Rossing… - Seminars in cancer …, 2022 - Elsevier
Multiple endocrine neoplasias are rare hereditary syndromes some of them with malignant
potential. Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary …

Molecular diagnostics in the evaluation of thyroid nodules: current use and prospective opportunities

J Patel, J Klopper, EE Cottrill - Frontiers in endocrinology, 2023 - frontiersin.org
Thyroid cancer is the most common endocrine malignancy with an estimated 43,800 new
cases to be diagnosed in 2022 and representing the 7th most common cancer in women …

Non-coding RNA in thyroid cancer-Functions and mechanisms

J Cao, M Zhang, L Zhang, J Lou, F Zhou, M Fang - Cancer letters, 2021 - Elsevier
Thyroid cancer is the most common endocrine malignant tumor, and its incidence has
increased significantly in the past few years. A growing number of noncoding RNAs …

Molecular imaging and theragnostics of thyroid cancers

L Giovanella, D Deandreis, A Vrachimis, A Campenni… - Cancers, 2022 - mdpi.com
Simple Summary According to the American Cancer Society, approximately 53,000 new
cases of thyroid cancer were diagnosed and more than 2200 people died from the disease …