Recent years have seen so-called natural killer T (NKT) cells emerge as important
regulators of the immune response. The existence of NKT-cell subsets, and other types of T …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

The proposed roles of NK1. 1+ T (NKT) cells in immune responses range from suppression
of autoimmunity to tumor rejection. Heterogeneity of these cells contributes to the …

The CD1 family of major histocompatibility complex (MHC)-like molecules specializes in
presenting lipid and glycolipid antigens to α/β T lymphocytes, but little is known about the …

Natural killer T (NKT) cells combine features of the innate and adaptive immune systems.
Recently, it has become evident that these T cells have crucial roles in the response to …

The development of CD1d-dependent natural killer T (NKT) cells is poorly understood. We
have used both CD1d/α-galactosylceramide (CD1d/αGC) tetramers and anti-NK1. 1 to …

Abstract Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human
CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles …

CD1d-restricted natural killer T (NKT) cells are a subset of regulatory T cells that react with
glycolipid antigens. Although preclinical studies have effectively targeted NKT cells for …

NKT cells are enigmatic lymphocytes that respond to glycolipid Ags presented by CD1d.
Although they are key immunoregulatory cells, with a critical role in immunity to cancer …

Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)–
restricted recognition of peptide fragments by conventional CD4+ helper T cells …