Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …

Paraoxonase 1 (PON1) is a high density lipoprotein (HDL)-associated enzyme displaying
esterase and lactonase activity. PON1 hydrolyzes several organophosphorus (OP) …

BACKGROUND: Paraoxonase enzyme was first identified as a protective barrier against
organophosphorus poisoning. After painstaking research spanning the last three decades …

Variation in paraoxonase-1 activity and atherosclerosis : Current Opinion in Lipidology
Variation in paraoxonase-1 activity and atherosclerosis : Current Opinion in Lipidology Log in or …

Extensive research has been carried out to understand and elucidate the mechanisms of
paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular …

Paraoxonase-1 (PON1) is a calcium-dependent, HDL-bound serum hydrolase active toward
a wide variety of substrates. PON1 displays three types of activities, among which lactonase …

Abstract Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) treat
dyslipidaemia and cardiovascular disease by inhibiting cholesterol biosynthesis. They also …

Abstract Human serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is
physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL …

HDL is a lipoprotein that plays a central role in reverse cholesterol transport (RCT). Hypo-
HDL-cholesterolemia has long been recognized as a strong and independent risk factor for …

Paraoxonase 1 (PON1) is an antioxidant enzyme attached to HDL with an anti-atherogenic
potential. It protects LDL and HDL from lipid peroxidation. The enzyme is sensitive to various …