Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) is a member of the NLR
family. The NLRP1 inflammasome consists of the NLRP1 protein, the adaptor protein …

Background—In the last 3 decades, and from a therapeutic point of view, the classical
concept of ischemic penumbra based on hemodynamic and electrophysiological …

Purpose To validate the use of perfusion computed tomography (CT) with whole-brain
coverage to measure the ischemic penumbra and core and to compare its performance to …

Penumbra is the viable tissue around the irreversibly damaged ischemic core. The purpose
of acute stroke treatment is to salvage penumbral tissue and to improve brain function …

The impact of reperfusion therapies on cognition has been poorly explored and little
knowledge exists. We explored the influence of endovascular treatment (EVT) on cognitive …

Stroke is the leading cause of death and physical disability worldwide. Non-coding RNAs
(ncRNAs) are endogenous molecules that play key roles in the pathophysiology and …

Berberine, a primary pharmacological active constitute of Coptidis Rhizoma, could inhibit
neuronal apoptosis in cerebral ischemia. Here, we aimed to investigate whether and how …

Stroke is a major cause of morbidity and mortality worldwide, and extensive efforts have
focused on the improvement of therapeutic strategies to reduce cell death following ischemic …

Stroke is the world's second leading cause of mortality, with a high incidence of morbidity.
Numerous neuronal membrane receptors are activated by endogenous ligands and may …