Stress and Hypothalamic–Pituitary–Adrenal (HPA) axis dysregulation play a major role in
various pathophysiological processes associated with both mood disorders and suicidal …

Abstract FK506 (Tacrolimus), isolated from Streptomyces tsukubaenis is a powerful
immunosuppressant shown to inhibit T cell activation. FK506 mediated immunosuppression …

Stress-induced mental health disorders are affecting many people around the world.
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …

The very incomprehensibility of the suicidal act has been occupying the minds of
researchers and health professionals for a long time. Several theories of suicide have been …

Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5
(mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography …

This review portraits FK506 binding protein (FKBP) 51 as “reactivity protein” and collates
recent publications to develop the concept of FKBP51 as contributor to different levels of …

Psychiatric disorders are complex polygenic diseases that show common genetic
vulnerability. Several studies have investigated the association of polymorphisms of FK506 …

Suicide is a major cause of death worldwide. Several biological systems have been
implicated in suicidal behavior but studies of candidate biomarkers have failed to produce …

Suicidal behavior is a major cause of morbidity and mortality in psychiatric illness. However,
only a subset of patients with psychiatric illnesses, such as major depressive disorder …

Chronic pain development is a frequent outcome of severe stressor exposure, with or
without tissue injury. Enduring stress-induced hyperalgesia (ESIH) is believed to play a …