The extended granin family: structure, function, and biomedical implications
A Bartolomucci, R Possenti, SK Mahata… - Endocrine …, 2011 - academic.oup.com
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …
Neuroendocrine role for VGF
The vgf gene (non-acronymic) is highly conserved and was identified on the basis of its
rapid induction in vitro by nerve growth factor, although can also be induced by brain …
rapid induction in vitro by nerve growth factor, although can also be induced by brain …
Two divergent leptin paralogues in zebrafish (Danio rerio) that originate early in teleostean evolution
The production of peptide hormones by skeletal muscle tissue is a promising area of gene
therapy. Skeletal muscle myogenesis can be induced in vitro, resulting in the fusion of …
therapy. Skeletal muscle myogenesis can be induced in vitro, resulting in the fusion of …
Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells
S Hannedouche, V Beck, J Leighton-Davies… - Journal of Biological …, 2013 - ASBMB
TLQP-21, a peptide derived from VGF (non-acronymic) by proteolytic processing, has been
shown to modulate energy metabolism, differentiation, and cellular response to stress …
shown to modulate energy metabolism, differentiation, and cellular response to stress …
[HTML][HTML] A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function
SB Stephens, JC Schisler, HE Hohmeier, J An, AY Sun… - Cell metabolism, 2012 - cell.com
Deterioration of functional islet β-cell mass is the final step in progression to Type 2
diabetes. We previously reported that overexpression of Nkx6. 1 in rat islets has the dual …
diabetes. We previously reported that overexpression of Nkx6. 1 in rat islets has the dual …
The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism
Summary TLQP-21, a VGF-encoded peptide is emerging as a novel target for obesity-
associated disorders. TLQP-21 is found in the sympathetic nerve terminals in the adipose …
associated disorders. TLQP-21 is found in the sympathetic nerve terminals in the adipose …
[HTML][HTML] VGF: A prospective biomarker and therapeutic target for neuroendocrine and nervous system disorders
Y Wang, X Qin, Y Han, B Li - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Neuroendocrine regulatory polypeptide VGF (nerve growth factor inducible) was firstly found
in the rapid induction of nerve growth factor on PC12 cells. It was selectively distributed in …
in the rapid induction of nerve growth factor on PC12 cells. It was selectively distributed in …
VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers
GL Ferri, B Noli, C Brancia, F D'Amato… - Journal of chemical …, 2011 - Elsevier
The vgf gene (non-acronymic) is induced in vivo by neurotrophins including Nerve Growth
Factor (NGF), Brain Derived Growth Factor (BDNF) and Glial Derived Growth Factor (GDNF) …
Factor (NGF), Brain Derived Growth Factor (BDNF) and Glial Derived Growth Factor (GDNF) …
The VGF-derived peptide TLQP21 impairs purinergic control of chemotaxis and phagocytosis in mouse microglia
Microglial cells are considered as sensors of brain pathology by detecting any sign of brain
lesions, infections, or dysfunction and can influence the onset and progression of …
lesions, infections, or dysfunction and can influence the onset and progression of …
Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders
A Bartolomucci, GM Pasinetti, SRJ Salton - Neuroscience, 2010 - Elsevier
The identification of biomarkers represents a fundamental medical advance that can lead to
an improved understanding of disease pathogenesis, and holds the potential to define …
an improved understanding of disease pathogenesis, and holds the potential to define …