Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

There is growing appreciation of key roles of the gut microbiota in maintaining homeostasis
and influencing brain and behaviour at critical windows across the lifespan. Mounting …

Microglia are the tissue-resident macrophage population of the brain, specialized in
supporting the CNS environment and protecting it from endogenous and exogenous insults …

Highlights•Microbe-derived molecules influence disease outcomes through diverse
mechanisms.•Short-chain fatty acid (SCFA) production in the gut can alter microglial …

Myeloid cells in the central nervous system (CNS), such as microglia, CNS-associated
macrophages (CAMs), dendritic cells and monocytes, are vital for steady-state immune …

The physiological consequences of stress often manifest in the gastrointestinal tract.
Traumatic or chronic stress is associated with widespread maladaptive changes throughout …

Central nervous system (CNS) diseases have become one of the leading causes of death in
the global population. The pathogenesis of CNS diseases is complicated, so it is important …

The gut microbiota has been found to interact with the brain through the microbiota–gut–
brain axis, regulating various physiological processes. In recent years, the impacts of the gut …