Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …

Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

BACKGROUND Male infertility affects> 20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has …

The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …

Small cell lung cancer (SCLC) accounts for 15% of lung cancers and is almost always linked
to inactivating RB1 and TP53 mutations. SCLC frequently responds, albeit briefly, to …

In the plant kingdom, events of whole genome duplication or polyploidization are generally
believed to occur via alterations of the sexual reproduction process. Thereby, diploid pollen …

Cell cycle deregulation is a common feature of human cancer. Tumor cells accumulate
mutations that result in unscheduled proliferation, genomic instability and chromosomal …