Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Statins, a class of cholesterol-lowering medications that inhibit 3-hydroxy-3-methyl-glutaryl-
coenzyme A reductase, are commonly administered to treat atherosclerotic cardiovascular …

Adequate availability of cellular building blocks, including lipids, is a prerequisite for cellular
proliferation, but excess dietary lipids are linked to increased cancer risk. Despite these …

Background & Aims Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol
biosynthesis, is suggested as a proto-oncogene. Paradoxically, SQLE is degraded by …

Background: Whether statin type influences hepatocellular carcinoma (HCC) incidence or
mortality in chronic hepatitis B or C virus infection is unknown. Objective: To assess the …

BACKGROUND: The existing scores reflecting the patient's nutritional and inflammatory
status do not include all biomarkers and have been poorly studied in colorectal cancers …

Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the
translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) …

Despite extensive research in the cancer field, cancer remains one of the most prevalent
diseases. There is an urgent need to identify specific targets that are safe and effective for …

Excess adiposity is a risk factor for several cancer types. This is likely due to complex
mechanisms including alterations in the lipid milieu that plays a pivotal role in multiple …

Background Activating mutations in KRAS frequently occur in colorectal cancer (CRC)
patients, leading to resistance to EGFR-targeted therapies. Methods To better understand …