Mitochondria in early development: linking the microenvironment, metabolism and the epigenome
AJ Harvey - Reproduction, 2019 - rep.bioscientifica.com
Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …
Methionine is a metabolic dependency of tumor-initiating cells
Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …
[PDF][PDF] Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development
Internal modification of RNAs with N 6-methyladenosine (m 6 A) is a highly conserved
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …
Environmentally relevant concentrations of carbamazepine induce liver histopathological changes and a gender-specific response in hepatic proteome of Chinese …
To assess hepatotoxicity and to determine the underlying mechanisms of carbamazepine
(CBZ) toxicity in fish, histopathology and the liver proteome were examined after Chinese …
(CBZ) toxicity in fish, histopathology and the liver proteome were examined after Chinese …
Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition
H Sun, J Kang, J Su, J Zhang, L Zhang… - Biology of …, 2019 - academic.oup.com
Abstract Methionine adenosyltransferase II (MAT2A) is essential to the synthesis of S-
adenosylmethionine, a major methyl donor, from L-methionine and ATP. Upon fertilization …
adenosylmethionine, a major methyl donor, from L-methionine and ATP. Upon fertilization …
Interspecific variation in one-carbon metabolism within the ovarian follicle, oocyte, and preimplantation embryo: consequences for epigenetic programming of DNA …
CE Clare, V Pestinger, WY Kwong, DAR Tutt… - International Journal of …, 2021 - mdpi.com
One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation of
purines and pyrimidines, biogenic amines, proteins, and phospholipids. Our understanding …
purines and pyrimidines, biogenic amines, proteins, and phospholipids. Our understanding …
CBS and MAT2A improve methionine‐mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation
S Cai, Q Ye, X Zeng, G Yang, C Ye, M Chen… - Cell …, 2021 - Wiley Online Library
Objectives Early pregnancy loss is a major clinical concern in animal and human
reproduction, which is largely influenced by embryo implantation. The importance of …
reproduction, which is largely influenced by embryo implantation. The importance of …
Long‐term culture of undifferentiated spermatogonia isolated from immature and adult bovine testes
Suyatno, Y Kitamura, S Ikeda, N Minami… - Molecular …, 2018 - Wiley Online Library
Undifferentiated spermatogonia eventually differentiate in the testis to produce haploid
sperm. Within this cell population, there is a small number of spermatogonial stem cells …
sperm. Within this cell population, there is a small number of spermatogonial stem cells …
Embryonic MTHFR contributes to blastocyst development
H Ishitani, S Ikeda, K Egashira, M Sugimoto… - Journal of Assisted …, 2020 - Springer
Purpose Reduction in methylenetetrahydrofolate reductase (MTHFR) activity due to genetic
variations in the MTHFR gene has been controversially implicated in subfertility in human in …
variations in the MTHFR gene has been controversially implicated in subfertility in human in …
The effects of rumen protected methionine supplementation on the performance of primiparous dairy cows using the Presynch‐Ovsynch protocol
The purpose of this study was to examine the effects of rumen‐protected methionine (RPM)
supplementation on the reproductive and productive performance of primiparous dairy cows …
supplementation on the reproductive and productive performance of primiparous dairy cows …