Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade

RA Cunha - Purinergic signalling, 2005 - Springer
Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …

The septohippocampal pathway: structure and function of a central cholinergic system.

P Dutar, MH Bassant, MC Senut… - Physiological …, 1995 - journals.physiology.org
Although the interest in the septohippocampal (SH) pathway is not recent [see the series of
papers by Petsche and co-workers in the 1960s (436, 437)], its study has been hampered for …

Calcium and the aging nervous system

GE Gibson, C Peterson - Neurobiology of aging, 1987 - Elsevier
Many aspects of calcium homeostasis change with aging. Numerous calcium compartments
complicate studies of altered calcium regulation. However, age-related decreases in calcium …

Cortical cholinergic fibers in aging and Alzheimer's disease: a morphometric study

C Geula, MM Mesulam - Neuroscience, 1989 - Elsevier
A histochemical method for acetylcholinesterase was used to assess the regional density of
acetylcholinesterase-rich (putatively cholinergic) axons in the cerebral cortex. A dense …

The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system

MW Decker - Brain Research Reviews, 1987 - Elsevier
It has been proposed that disruption of cholinergic input to the hippocampus and cortex
contributes to the learning and memory deficits associated with aging. The data reviewed …

Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats

W Fischer, FH Gage, A Björklund - European Journal of …, 1989 - Wiley Online Library
Degenerative changes in the forebrain cholinergic nuclei have been studied
morphometrically in behaviourally characterized aged female Sprague‐Dawley rats. In all …

Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain

A Sato, Y Sato - Neuroscience research, 1992 - Elsevier
We review mainly recent studies on vasodilative regulation of cortex and hippocampus by
central cholinergic nerves originating in the basal forebrain. We also briefly review the …

Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis

CF Wu, R Bertorelli, M Sacconi, G Pepeu… - Neurobiology of …, 1988 - Elsevier
In vivo extracellular acetylcholine release from brain hemispheric areas of 2-, 9-, and 18-
month-old rats was measured by intracerebral microdialysis coupled with a radioenzymatic …

Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats

Q Zheng, K Olivier, YK Won, CN Pope - Toxicological Sciences, 2000 - academic.oup.com
Chlorpyrifos (CPF) is a common organophosphorus (OP) pesticide. Previous studies have
demonstrated that neonatal rats are more sensitive than adults to the acute toxicity of high …

Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats

S Ando, T Tadenuma, Y Tanaka, F Fukui… - Journal of …, 2001 - Wiley Online Library
The effects of a carnitine derivative, acetyl‐L‐carnitine (ALCAR), on the cognitive and
cholinergic activities of aging rats were examined. Rats were given ALCAR (100 mg/kg) per …