NADPH metabolism: a survey of its theoretical characteristics and manipulation strategies in amino acid biosynthesis

JZ Xu, HK Yang, WG Zhang - Critical Reviews in Biotechnology, 2018 - Taylor & Francis
Reduced nicotinamide adenine nucleotide phosphate (NADPH), which is one of the key
cofactors in the metabolic network, plays an important role in the biochemical reactions, and …

l-arginine production in Corynebacterium glutamicum: manipulation and optimization of the metabolic process

Y Jiang, Q Sheng, XY Wu, BC Ye… - Critical Reviews in …, 2021 - Taylor & Francis
As an important semi-essential amino acid, l-arginine is extensively used in the food and
pharmaceutical fields. At present, l-arginine production depends on cost-effective, green …

Reengineering of the feedback-inhibition enzyme N-acetyl-l-glutamate kinase to enhance l-arginine production in Corynebacterium crenatum

J Zhang, M Xu, X Ge, X Zhang, T Yang… - Journal of Industrial …, 2017 - academic.oup.com
N-acetyl-l-glutamate kinase (NAGK) catalyzes the second step of l-arginine biosynthesis and
is inhibited by l-arginine in Corynebacterium crenatum. To ascertain the basis for the …

Recent advances in amino acid production

M Ikeda, S Takeno - Corynebacterium Glutamicum: Biology and …, 2020 - Springer
The annual world production of amino acids is currently estimated at more than seven
million tons and is expected to reach ten million tons by 2022. This giant market has been …

[HTML][HTML] Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus

Y Xie, Q Li, X Qin, J Ju, J Ma - Metabolic Engineering Communications, 2019 - Elsevier
Three atypical regulatory genes, hmtABD have been discovered within the himastatin
biosynthetic gene cluster (BGC) in Streptomyces hygroscopicus ATCC 53653 and the roles …

Unique Proteomes Implicate Functional Specialization across Heterocysts, Akinetes, and Vegetative Cells in Anabaena cylindrica

Y Qiu, L Gu, V Brözel, D Whitten, M Hildreth, R Zhou - bioRxiv, 2020 - biorxiv.org
In response to environmental changes, vegetative cells of Anabaena cylindrica can
differentiate into two other cell types: a heterocyst for oxic N2-fixation, and an enlarged spore …

Conformational dynamics play important roles upon the function of N-acetylglutamate kinase

X Yang - Applied microbiology and biotechnology, 2017 - Springer
N-acetylglutamate kinase (NAGK) catalyzes the phosphorylation of N-acetylglutamate. In
many bacteria, NAGK catalysis is the rate controlling step in the L-arginine biosynthesis …

System Metabolic Engineering Applications in Corynebacterium crenatum for l-Arginine Production

Z Rao, M Xu, Z Xu - Current developments in biotechnology and …, 2019 - Elsevier
Abstract l-Arginine is an important amino acid in food and pharmaceutical industries. The
industrial level of l-arginine production by microbial fermentation has become an important …