Cannabinoids and pain: sites and mechanisms of action
K Starowicz, DP Finn - Advances in Pharmacology, 2017 - Elsevier
The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
Intracellular peptides in cell biology and pharmacology
Intracellular peptides are produced by proteasomes following degradation of nuclear,
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …
Hemopressin as a breakthrough for the cannabinoid field
Hemopressin (PVNFKFLSH in rats, and PVNFKLLSH in humans and mice), a fragment
derived from the α-chain of hemoglobin, was the first peptide described to have type 1 …
derived from the α-chain of hemoglobin, was the first peptide described to have type 1 …
The electrophysiological and behavioral evaluation of the peptide hemopressin and cannabinoid CB1 receptor agonist and antagonist in pentylenetetrazol model of …
A Al-Kaleel, H Aygun, L Al-Gailani, Y Kabak… - … -European Journal of …, 2023 - Springer
This study endeavoured to assess the effect of hemopressin (Hp), a nano peptide obtained
from the alpha chain of hemoglobin, on chronic epileptic activity and its potential correlation …
from the alpha chain of hemoglobin, on chronic epileptic activity and its potential correlation …
Microglial Cannabinoid CB2 Receptors in Pain Modulation
K Xu, Y Wu, Z Tian, Y Xu, C Wu, Z Wang - International Journal of …, 2023 - mdpi.com
Pain, especially chronic pain, can strongly affect patients' quality of life. Cannabinoids
ponhave been reported to produce potent analgesic effects in different preclinical pain …
ponhave been reported to produce potent analgesic effects in different preclinical pain …
Effects of the cannabinoid 1 receptor peptide ligands hemopressin,(m) RVD-hemopressin (α) and (m) VD-hemopressin (α) on memory in novel object and object …
Z He, W Jin, R Wang - Neurobiology of Learning and Memory, 2016 - Elsevier
The cannabinoid system plays an important role in memory processes, many studies have
indicated that cannabinoid receptor ligands have ability to modulate memory in rodents. A …
indicated that cannabinoid receptor ligands have ability to modulate memory in rodents. A …
New insights into peptide cannabinoids: structure, biosynthesis and signaling
A Riquelme-Sandoval, CO de Sá-Ferreira… - Frontiers in …, 2020 - frontiersin.org
Classically, the endocannabinoid system (ECS) consists of endogenous lipids, of which the
best known are anandamide (AEA) and 2 arachidonoylglycerol (2-AG), their enzyme …
best known are anandamide (AEA) and 2 arachidonoylglycerol (2-AG), their enzyme …
Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice
Background Hemopressin was identified as an endogenous inverse agonist/antagonist of
CB 1 receptor, whereas VD‐hemopressin (α)[VD‐Hpα] and VD‐hemopressin (β)[VD‐Hpβ] …
CB 1 receptor, whereas VD‐hemopressin (α)[VD‐Hpα] and VD‐hemopressin (β)[VD‐Hpβ] …
Signaling molecules targeting cannabinoid receptors: Hemopressin and related peptides
F Wei, L Zhao, Y Jing - Neuropeptides, 2020 - Elsevier
Cannabinoid receptors (CBRs) are part of the endocannabinoid system, which is involved in
various physiological processes such as nociception, inflammation, appetite, stress, and …
various physiological processes such as nociception, inflammation, appetite, stress, and …
Investigation of receptor binding and functional characteristics of hemopressin (1–7)
The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp (1–9)) and its
truncated (PVNFKFL, Hp (1–7) and PVNFKF, Hp (1–6)) and extended ((R) VDPVNFKFLSH …
truncated (PVNFKFL, Hp (1–7) and PVNFKF, Hp (1–6)) and extended ((R) VDPVNFKFLSH …