Several hundreds of studies recently investigated mean platelet volume (MPV) as measured
by electronic cell counters in a wide variety of acquired diseases, and most of them found …

In healthy subjects and patients with hematological diseases, platelet populations can be
distinguished with different response spectra in hemostatic and vascular processes. These …

The imbalance between reactive oxygen species (ROS) synthesis and their scavenging by
anti-oxidant defences is the common soil of many disorders, including …

The vitamin D receptor (VDR) is a ligand-activated transcription factor that regulates gene
expression in many cell types, including immune cells. It requires binding of 1, 25 dihydroxy …

The proprotein convertase subtilisin/keying 9 (PCSK9) is a serine protease that has gained
importance in recent years as a drug target, mainly due to its effect on cholesterol …

Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a novel group of
hypolipidemic drugs that are recommended particularly for high-risk hypercholesterolemia …

Background Mean platelet volume (MPV) correlates with platelet activation and has recently
emerged as a potential marker of cardiovascular diseases. Previous publications also …

For almost a century, familial hypercholesterolemia (FH) has been considered a serious
disease, causing atherosclerosis, cardiovascular disease, and ischemic stroke. Closely …

Familial hypercholesterolemia is a common genetic disorder with a propensity towards early
onset of atherosclerotic cardiovascular disease (CVD). The main goal of therapy is to reduce …

High low-density-lipoprotein cholesterol (LDL-C) is routinely described as the main cause of
cardiovascular disease (CVD) in familial hypercholesterolemia (FH). However, numerous …