[HTML][HTML] The function of introns
The intron–exon architecture of many eukaryotic genes raises the intriguing question of
whether this unique organization serves any function, or is it simply a result of the spread of …
whether this unique organization serves any function, or is it simply a result of the spread of …
Nonsense‐mediated mRNA decay: novel mechanistic insights and biological impact
ED Karousis, S Nasif… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control
mechanism that targets mRNAs with truncated open reading frames due to the presence of a …
mechanism that targets mRNAs with truncated open reading frames due to the presence of a …
[PDF][PDF] The functional impact of alternative splicing in cancer
Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …
recognized as important signatures for tumor progression and therapy. However, their …
Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis
Alternative splicing (AS) coupled to nonsense-mediated decay (NMD) is a post-
transcriptional mechanism for regulating gene expression. We have used a high-resolution …
transcriptional mechanism for regulating gene expression. We have used a high-resolution …
[HTML][HTML] The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus
In addition to sculpting eukaryotic transcripts by removing introns, pre-mRNA splicing greatly
impacts protein composition of the emerging mRNP. The exon junction complex (EJC) …
impacts protein composition of the emerging mRNP. The exon junction complex (EJC) …
Modelling and simulating generic RNA-Seq experiments with the flux simulator
High-throughput sequencing of cDNA libraries constructed from cellular RNA complements
(RNA-Seq) naturally provides a digital quantitative measurement for every expressed RNA …
(RNA-Seq) naturally provides a digital quantitative measurement for every expressed RNA …
Interplay between gene expression noise and regulatory network architecture
G Chalancon, CNJ Ravarani, S Balaji… - Trends in genetics, 2012 - cell.com
Complex regulatory networks orchestrate most cellular processes in biological systems.
Genes in such networks are subject to expression noise, resulting in isogenic cell …
Genes in such networks are subject to expression noise, resulting in isogenic cell …
Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay
JA Hurt, AD Robertson, CB Burge - Genome research, 2013 - genome.cshlp.org
UPF1 is a DNA/RNA helicase with essential roles in nonsense-mediated mRNA decay
(NMD) and embryonic development. How UPF1 regulates target abundance and the …
(NMD) and embryonic development. How UPF1 regulates target abundance and the …
Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6-and SMG7-mediated degradation pathways
M Colombo, ED Karousis, J Bourquin, R Bruggmann… - Rna, 2017 - rnajournal.cshlp.org
Besides degrading aberrant mRNAs that harbor a premature translation termination codon
(PTC), nonsense-mediated mRNA decay (NMD) also targets many seemingly “normal” …
(PTC), nonsense-mediated mRNA decay (NMD) also targets many seemingly “normal” …
Autoregulation of the nonsense-mediated mRNA decay pathway in human cells
H Yepiskoposyan, F Aeschimann, D Nilsson… - Rna, 2011 - rnajournal.cshlp.org
Nonsense-mediated mRNA decay (NMD) is traditionally portrayed as a quality-control
mechanism that degrades mRNAs with truncated open reading frames (ORFs). However, it …
mechanism that degrades mRNAs with truncated open reading frames (ORFs). However, it …