β-Catenin: oncogenic role and therapeutic target in cervical cancer

B Wang, X Li, L Liu, M Wang - Biological research, 2020 - Springer
Cervical cancer is a common and fatal malignancy of the female reproductive system.
Human papillomavirus (HPV) is the primary causal agent for cervical cancer, but HPV …

Dietary isothiocyanates inhibit cancer progression by modulation of epigenome

MK Sundaram, R Preetha, S Haque, N Akhter… - Seminars in Cancer …, 2022 - Elsevier
Cell cycle, growth, survival and metabolism are tightly regulated together and failure in
cellular regulation leads to carcinogenesis. Several signaling pathways like the PI3K, WNT …

Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo

I Ramachandran, E Thavathiru, S Ramalingam… - Oncogene, 2012 - nature.com
Aberrant activation of Wingless-type (Wnt)/β-catenin signaling is widespread in human
cervical cancer. However, the underlying mechanisms of Wnt activation and the therapeutic …

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

J Lee, DJ Jeong, J Kim, S Lee, JH Park, B Chang… - Molecular cancer, 2010 - Springer
Background Klotho was originally characterized as an anti-aging gene that predisposed
Klotho-deficient mice to a premature aging-like syndrome. Recently, KLOTHO was reported …

Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells

PC Thacker, D Karunagaran - PloS one, 2015 - journals.plos.org
Cervical cancer is the major cause of cancer related deaths in women, especially in
developing countries and Human Papilloma Virus infection in conjunction with multiple …

A human papillomavirus-independent cervical cancer animal model reveals unconventional mechanisms of cervical carcinogenesis

C He, X Lv, C Huang, PC Angeletti, G Hua, J Dong… - Cell reports, 2019 - cell.com
HPV infections are common in healthy women and only rarely cause cervical cancer,
suggesting that individual genetic susceptibility may play a critical role in the establishment …

MicroRNAs in cervical cancer: evidences for a miRNA profile deregulated by HPV and its impact on radio-resistance

A Pedroza-Torres, E López-Urrutia, V García-Castillo… - Molecules, 2014 - mdpi.com
Cervical carcinoma (CC) is one of the most common cancers and a leading cause of
mortality in women worldwide. Epidemiologic and experimental data have clearly …

Interplay between autophagy and Wnt/β-catenin signaling in cancer: therapeutic potential through drug repositioning

C Pérez-Plasencia, E López-Urrutia… - Frontiers in …, 2020 - frontiersin.org
The widespread dysregulation that characterizes cancer cells has been dissected and many
regulation pathways common to multiple cancer types have been described in depth. Wnt/β …

Clinical significance and prognosis value of Wnt signaling pathway in cervical cancer

A Bahrami, M Hasanzadeh… - Journal of cellular …, 2017 - Wiley Online Library
Cervical cancer is among the most commonly diagnosed cancer in women, supporting the
need for identification of novel prognostic and predictive biomarkers to predict the risk of …

AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity

HT Kwan, DW Chan, PCH Cai, CSL Mak, MMH Yung… - PLoS …, 2013 - journals.plos.org
Recent evidence has suggested that AMPK activators may be applied as therapeutic drugs
in suppressing cancer cell growth. However, the molecular mechanism of their suppressive …