Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates
protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by …

Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides.
While the 11 PDE subfamilies share common features, key differences confer signaling …

Background Although the development of therapies for heart failure (HF) continues apace,
clinical outcomes are often far from ideal. Unc51-like-kinase 1 (ULK1)-mediated mitophagy …

The mechanistic target of rapamycin (mTOR) kinase is a central regulator of cell growth and
metabolism. It is the catalytic subunit of two distinct large protein complexes, mTOR complex …

The mechanistic target of rapamycin (mTOR) complex 1, mTORC1, integrates nutrient and
growth factor signals with cellular responses and plays critical roles in regulating cell growth …

The mechanistic target of rapamycin (mTOR) integrates several intracellular and
extracellular signals involved in the regulation of anabolic and catabolic processes. mTOR …

Rationale: The mTORC1 (mechanistic target of rapamycin complex-1) controls metabolism
and protein homeostasis and is activated following ischemia reperfusion (IR) injury and by …

Circadian rhythms are physical, behavioral and environmental cycles that respond primarily
to light and dark, with a period of time of approximately 24 h. The most essential …

Precision-based molecular phenotyping of heart failure must overcome limited access to
cardiac tissue. Although epigenetic alterations have been found to underlie pathological …

Background: Cardiac autophagic flux is impaired during myocardial ischemia/reperfusion
(MI/R). Impaired autophagic flux may exacerbate MI/R injury. Charged multivesicular body …