Since the discovery of the histamine H 3 receptor in 1983, tremendous advances in the
pharmacological aspects of H 3 receptor antagonists/inverse agonists have been …

Age-related neurodegenerative disorders such as Alzheimer's disease (AD) have become a
critical public health issue due to the significantly extended human lifespan, leading to …

Anxiety-and depression-like behavior following chemotherapy treatment occurs in cancer
patients with high probability and no specific therapeutics are available for treatment and …

A relationship appears to exist between dysfunction of brain histamine (HA) and various
neuropsychiatric brain disorders. The possible involvement of brain HA in neuropathology …

Adult neurogenesis in hippocampus dentate gyrus (DG) is associated with numerous
neurodegenerative diseases such as aging and Alzheimer's disease (AD). Overactivation of …

A phenomenon called vestibular compensation occurs after peripheral vestibular loss. This
process involves a mosaic of profound structural rearrangements within the vestibular …

Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated
plasma corticosterone (CORT) correlates with reduced levels of both brain-derived …

Epilepsy is a prevalent and chronic neurological disorder marked by recurring,
uncontrollable seizures of the brain. Chronic or repeated seizures produce memory …

Evidence points to a dual role of histamine in microglia-mediated neuroinflammation, a key
pathological feature of several neurodegenerative pathologies. Moreover, histamine has …

Histamine performs dual roles as an immune regulator and a neurotransmitter in the
mammalian brain. The histaminergic system plays a vital role in the regulation of …