Aptamer bioinformatics

AB Kinghorn, LA Fraser, S Liang, SCC Shiu… - International journal of …, 2017 - mdpi.com
Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular
binding. They are isolated via SELEX (Systematic Evolution of Ligands by Exponential …

Computational Selection of RNA Aptamer against Angiopoietin‐2 and Experimental Evaluation

WP Hu, JV Kumar, CJ Huang… - BioMed research …, 2015 - Wiley Online Library
Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin‐2
(Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of …

In-Silico Selection of Aptamer Targeting SARS-CoV-2 Spike Protein

YC Lin, WY Chen, ET Hwu, WP Hu - International Journal of Molecular …, 2022 - mdpi.com
Aptamers are single-stranded, short DNA or RNA oligonucleotides that can specifically bind
to various target molecules. To diagnose the infected cases of severe acute respiratory …

Thrombin inhibitory peptides derived from Mytilus edulis proteins: identification, molecular docking and in silico prediction of toxicity

L Feng, M Tu, M Qiao, F Fan, H Chen, W Song… - … Food Research and …, 2018 - Springer
Optimization of the thrombin inhibitory activities of different enzymatic hydrolysates was
conducted, and then an optimal hydrolysis condition by trypsin (5000 u/g) was determined …

Investigating interactions between proteins and nucleic acids by computational approaches

WP Hu, HT Lin, JJP Tsai, WY Chen - Computational Methods with …, 2017 - books.google.com
Molecular simulations are wildly used in studying many types of biomolecular interactions,
such as protein-protein interaction, drugreceptor interaction, protein-nucleic acid (NA) …

Computational Design of a New Aflatoxin B1 Aptamer in lieu of SELEX Technique

MY Ahmad Ghazy - bioRxiv, 2022 - biorxiv.org
Mycotoxins are extremely dangerous, and their detection in our environment, food and feed
is becoming increasingly important. Biosensors are being implemented heavily in mycotoxin …

A Study on the Binding Ability of Truncated Aptamers for the Prostate Specific Antigen Using Both Computational and Experimental Approaches

HT Lin, W Yang, WY Su, CJ Chan, WY Chen… - … and Applications (FC …, 2018 - Springer
Prostate-specific antigen (PSA) test is a commonly used clinical examination to evaluate the
risk of prostate cancer, with the antibodies used normally as the recognition molecules for …

The Selection of DNA Aptamers Against the Fc Region of Human IgG

WP Hu, HT Lin, WY Su, RM Hu, W Yang… - … and Applications (FC …, 2019 - Springer
Aptamers can bind with various kinds of target molecules and therefore they have highly
potential for using in the therapeutic, diagnostic, biosensing, purification applications, etc …