The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

Tissue-resident and recruited macrophages contribute to both host defense and pathology.
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …

Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its
underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte …

The immune system probably evolved to limit the negative effects exerted by pathogens on
host homeostasis. This defence strategy relies on the concerted action of innate and …

Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …

With age, skeletal muscle stem cells (MuSCs) activate out of quiescence more slowly and
with increased death, leading to defective muscle repair. To explore the molecular …

Immunity is a high-cost, high-benefit trait that defends against pathogens and noxious stimuli
but whose overactivation can result in immunopathologies and sometimes even death …