Melanoma is a potentially fatal skin malignancy that continues to increase in incidence
worldwide. The current lifetime risk of developing melanoma is 1 in 63 in the United States …

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

PURPOSE Germline testing (GT) is a central feature of prostate cancer (PCA) treatment,
management, and hereditary cancer assessment. Critical needs include optimized …

The NCCN Guidelines for Prostate Cancer include recommendations regarding diagnosis,
risk stratification and workup, treatment options for localized disease, and management of …

Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers,–, and disease-
specific screening and preventative strategies have reduced cancer mortality in affected …

Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

Serial circulating tumor DNA (ctDNA) monitoring is emerging as a non-invasive strategy to
predict and monitor immune checkpoint blockade (ICB) therapeutic efficacy across cancer …

DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …

Background BRCA1 and BRCA2 mutations have been associated with prostate cancer
(PCa) risk but a wide range of risk estimates have been reported that are based on …

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prostate Cancer
Early Detection provide recommendations for prostate cancer screening in healthy men who …