Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …

The availability of new antifungal agents with novel mechanisms of action has stimulated
renewed interest in combination antifungal therapies. In particular, and despite the limited …

With increasing numbers of immune-compromised patients with malignancy, hematologic
disease, and HIV, as well as those receiving immunosupressive drug regimens for the …

The need for safe and effective antifungal agents increases in parallel with the expanding
number of immunocompromised patients at risk for invasive fungal infections. The …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes cryptococcal
meningoencephalitis, particularly in immunocompromised patients. The fungal cell wall is an …

The in vitro antifungal activities of SCH56592, MK-0991, and LY303366 against 83 isolates
of Acremonium strictum, Aspergillus flavus, Aspergillus fumigatus, Aspergillus terreus …

The survival of all organisms depends critically upon interactions with the environment,
mediated largely through the action of small molecules. Small molecules can provide the …

Abstract Caspofungin (MK-0991; L-743,872) belongs to the echinocandin family, a new
class of antifungal agents that act on the fungal cell wall by inhibiting glucan synthesis. Data …

Caspofungin, a glucan synthesis inhibitor, is being developed as a parenteral antifungal
agent. The pharmacokinetics of caspofungin following 1-h intravenous infusions in healthy …

Chitin is an essential component of the cell wall of many fungi. Chitin also can be
enzymatically deacetylated to chitosan, a more flexible and soluble polymer. Cryptococcus …