Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …

Astrocytes, the most abundant cells in the central nervous system, promote synapse
formation and help to refine neural connectivity. Although they are allocated to spatially …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

How neurons develop their morphology is an important question in neurobiology. Here we
describe a new pathway that specifically affects the formation of basal dendrites and axonal …

Summary Semaphorin 3A (Sema3A) is a secreted factor known to guide axon/dendrite
growth and neuronal migration. We found that it also acts as a polarizing factor for …

Emerging evidence points to the involvement of the brain extracellular matrix (ECM) in the
pathophysiology of schizophrenia (SZ). Abnormalities affecting several ECM components …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

Highlights•Semaphorins affect the spatial distribution of synapses by regulating dendritic
arborization.•Semaphorins directly affect the formation of excitatory and inhibitory …

The highly specialized morphology of a neuron, typically consisting of a long axon and
multiple branching dendrites, lies at the core of the principle of dynamic polarization …