Atrial Fibrosis Mechanisms and Clinical Relevance in Atrial Fibrillation Brett Burstein,
Stanley Nattel Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Objectives: The aim of this report was to show that the rate of cardiovascular events is
increased in patients with either subtype of primary aldosteronism (PA). Background …

Background—The progression of compensated hypertrophy to heart failure (HF) is still
debated. We investigated patients with isolated valvular aortic stenosis and differing …

Objectives: This individually randomized, open-label, parallel-group pilot study was
designed to test the hypothesis that the ability of loop diuretics to interfere with cardiac …

Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting
up to 1% of the general population. Its prevalence exponentially increases with age and …

Background Hypertrophic cardiomyopathy is a genetic disease characterized by cardiac
hypertrophy, myocyte disarray, interstitial fibrosis, and left ventricular (LV) dysfunction. We …

Objective To investigate pathologic fibrosis and connective tissue matrix in left ventricular
hypertrophy due to chronic arterial hypertension in humans. Design and methods …

Fibrosis leads to chronic impairment of cardiac and renal function and thus reversal of
existing fibrosis may improve function and survival. This project has determined whether …

Background—Human hypertrophic cardiomyopathy (HCM), the most common cause of
sudden cardiac death in the young, is characterized by cardiac hypertrophy, myocyte …