Over the past decade, with the development of high-throughput single-cell sequencing
technology, single-cell omics has been emerged as a powerful tool to understand the …

Little is known about three-dimensional (3D) genome organization in skeletal muscle stem
cells [also called satellite cells (SCs)]. Here, we comprehensively map the 3D genome …

Highlights•Enhancers integrate important developmental signals into transcriptional
outputs.•Enhancers are controlled in a three-dimensional architecture.•Three-dimensional …

Four SIX homeoproteins display a combinatorial expression throughout embryonic
developmental myogenesis and they modulate the expression of the myogenic regulatory …

Here, we present workflows for integrating independent transcriptomic and chromatin
accessibility datasets and analyzing multiomics. First, we describe steps for integrating …

Preparing viable single cells is critical for conducting single‐cell RNA sequencing (scRNA‐
seq) because the presence of ambient RNA from dead or damaged cells can interfere with …

染色质三维基因组结构在细胞功能和基因调控中起着关键作用。 单细胞Hi-C
技术可以在细胞水平上捕获基因组结构信息， 这为研究不同细胞类型之间基因组结构的变化 …

Skeletal muscle stem cells (MuSCs), also known as satellite cells, are essential for muscle
growth and injury induced regeneration. In healthy adult muscle, MuSCs remain in a …

Mouse embryonic stem cells (mESCs) can be directed to acquire cell-lineage-specific
genetic programs and phenotypes by stepwise exposure to defined factors, allowing the …

染色质三维基因组结构在细胞功能和基因调控中起着关键作用. 单细胞 Hi-C
技术可以在细胞水平上捕获基因组结构信息, 这为研究不同细胞类型之间基因组结构的变化提供 …