Abstract N6-methyladenosine (m6A) is a widely investigated RNA modification in studies on
the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal …

Breast cancer (BC) has high incidence and mortality rates, making it a major global health
issue. BC treatment has been challenging due to the presence of drug resistance and the …

Background Tumor microenvironment (TME) plays important roles in different cancers. Our
study aimed to identify molecules with significant prognostic values and construct a relevant …

Cell cycle dysregulation is a hallmark of cancer that promotes eccessive cell division. Cyclin-
dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6) are key molecules in …

Endocrine therapy (ET) in combination with CDK4/6 inhibition is routinely used as first-line
treatment for HR+/HER2− metastatic breast cancer (MBC) patients. However, 30–40% of …

Aging exacerbates the dysfunction of tissue regeneration at multiple levels and gradually
diminishes individual's capacity to withstand stress, damage, and disease. The excessive …

Efficient entry into S phase of the cell cycle is necessary for embryonic development and
tissue homoeostasis. However, unscheduled S phase entry triggers DNA damage and …

Abstract The ATR-CHK1 DNA damage response pathway becomes activated by the
exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during …

Due to concealment, high invasiveness and a lack of indicators, malignant tumors have
emerged as one of the deadliest diseases worldwide and their incidence is rising yearly …

Understanding the organization of the cell cycle has been a longstanding goal in cell
biology. We combined time-lapse microscopy, highly multiplexed single-cell imaging of 48 …