New types of antidiabetic agents are continually needed with diabetes becoming the
epidemic in the world. Indole alkaloids play an important role in natural products owing to …

Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been
used clinically for the prevention and treatment of cerebrovascular disorders and …

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, which has yet
no curable medication. Neuroinflammation and mitochondrial dysfunction are tightly linked …

Obesity and metabolic disorders have gradually become public health-threatening
problems. The metabolic disorder is a cluster of complex metabolic abnormalities which are …

The progress made so far in the elucidation of the structure of free fatty acid receptor 1
(FFAR1) and its secondary and ternary complexes with partial and full allosteric ligands led …

A series of vincamine derivatives were designed, synthesized and evaluated as pancreatic β-
cells protective agents for type 2 diabetes mellitus. Most of the compounds displayed potent …

A novel series of 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides was designed,
synthesized and evaluated for their biological activities on glucose-stimulated insulin …

Background Pulmonary fibrosis (PF) is an irreversible and fatal lung disease with limited
therapeutic options. G protein-coupled receptor 40 (GPR40) has been developed as a …

Background: The global incidence of type 2 diabetes mellitus (T2DM) has enthused the
development of new antidiabetic targets with low toxicity and long-term stability. In this …

Xelaglifam, developed as a GPR40/FFAR1 agonist, induces glucose-dependent insulin
secretion and reduces circulating glucose levels for Type 2 diabetes treatment. This study …