Structure prediction for proteins lacking homologous templates in the Protein Data Bank
(PDB) remains a significant unsolved problem. We developed a protocol, CI-TASSER, to …

Around 6% of protein structures deposited in the PDB are entangled, forming knots,
slipknots, lassos, links, and θ-curves. In each of these cases, the protein backbone weaves …

The inapplicability of amino acid covariation methods to small protein families has limited
their use for structural annotation of whole genomes. Recently, deep learning has shown …

The potential of deep learning has been recognized in the protein structure prediction
community for some time, and became indisputable after CASP13. In CASP14, deep …

Deep learning-based prediction of protein structure usually begins by constructing a multiple
sequence alignment (MSA) containing homologs of the target protein. The most successful …

Crystallographers have an array of search-model options for structure solution by molecular
replacement (MR). The well established options of homologous experimental structures and …

The availability of 3D protein models is rapidly increasing with the development of structure
prediction algorithms. With the expanding availability of data, new ways of analysis …

Abstract Background Caucasian clover (Trifolium ambiguum M. Bieb.) is a strongly
rhizomatous, low-crowned perennial leguminous and ground-covering grass. The species …

The co-chaperone DnaJ plays an important role in protein folding and regulation of various
physiological activities, and participates in several pathological processes. DnaJ has been …

Molecular replacement (MR) is the predominant route to solution of the phase problem in
macromolecular crystallography. Where the lack of a suitable homologue precludes …