Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Neuroprosthetics is a multidisciplinary field at the interface between neurosciences and
biomedical engineering, which aims at replacing or modulating parts of the nervous system …

In recent decades, deep brain stimulation (DBS) has been extensively studied due to its
reversibility and significantly fewer side effects. DBS is mainly a symptomatic therapy, but the …

The root cause of non-inherited Alzheimer's disease (AD) remains unknown despite
hundreds of research studies performed to attempt to solve this problem. Since proper …

Cognitive deficits in Alzheimer's disease, specifically amnestic (memory dominant) deficits,
are associated with cholinergic degeneration in the basal forebrain. The cholinergic nucleus …

Alzheimer's disease (AD) poses a significant global health concern over the next several
decades. Multiple hypotheses have been put forth that attempt to explain the underlying …

Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has
shown potential for the treatment of mild-to-moderate Alzheimer's disease (AD). However …

Background: Cholinergic degeneration is strongly associated with cognitive decline in
patients with Parkinson's disease (PD) but may also cause motor symptoms and olfactory …

Alzheimer's disease is a growing global crisis in need of urgent diagnostic and therapeutic
strategies. The current treatment strategy mostly involves immunotherapeutic medications …

Alzheimer's disease (AD) is an advanced neurodegenerative disorder greatly accompanied
by cognitive deficits, oxidative stress, inflammation, amyloid plaques deposition, and …