NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Metabolism is a fundamental process that underlies human health and diseases. Nuclear
magnetic resonance (NMR) techniques offer a powerful approach to identify metabolic …

The central carbon metabolism of microbes will likely be used in future sustainable
bioproduction. A sufficiently deep understanding of central metabolism would advance the …

Serum albumin possesses esterase and pseudo-esterase activities towards a number of
endogenous and exogenous substrates, but the mechanism of interaction of various esters …

Insights into intracellular chemistry have remained sparse, but would be impactful for the
advancement of biomedicine and bioproduction. A suitable 13C NMR approach provides …

Saccharomyces cerevisiae has long been a pillar of biotechnological production and basic
research. More recently, strides to exploit the functional repertoire of nonconventional yeasts …

Pancreatic β-cells become irreversibly damaged by long-term exposure to excessive
glucose concentrations and lose their ability to carry out glucose stimulated insulin secretion …

Changes to metabolism are a hallmark of many diseases. Disease metabolism under
physiological conditions can be probed in real time with in-cell NMR assays. Here, we …

Many enzymes have latent activities that can be used in the conversion of non-natural
reactants for novel organic conversions. A classic example is the conversion of …