This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …

Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and
represent a potential treatment for a variety of neurodegenerative and neurological …

Parkinson's disease (PD) is the second most common neurodegenerative disease, the main
pathological hallmark of which is the accumulation of α-synuclein (α-syn) and the formation …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Neuroinflammation is one of the hallmarks of Parkinson's disease (PD) and may contribute
to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation …

Abstract α-synuclein is a small protein abundantly expressed in the brain and mainly located
in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark …

α-Synuclein (αSyn) aggregation and mitochondrial dysfunction both contribute to the
pathogenesis of Parkinson disease (PD). Although recent studies have suggested that …

Amyloid aggregation, which disrupts protein homeostasis, is a common pathological event
occurring in human neurodegenerative diseases (NDs). Numerous evidences have shown …

The protein alpha-synuclein is considered to play a major role in the etiology of Parkinson's
disease. Because it is found in a classic amyloid fibril form within the characteristic intra …