Recent applications of azo dyes: A paradigm shift from medicinal chemistry to biomedical sciences
MN Khan, DK Parmar, D Das - Mini Reviews in Medicinal …, 2021 - ingentaconnect.com
Azo molecules possess the characteristic azo bond (-N= N-) and are considered fascinating
motifs in organic chemistry. Since the last century, these brightly colored compounds have …
motifs in organic chemistry. Since the last century, these brightly colored compounds have …
An insight into synthetic strategies and recent developments of dihydrofolate reductase inhibitors
The dihydrofolate reductase (DHFR) is a significant target in cancer, microbial infection,
fungal infection, malaria, leishmaniasis, and tuberculosis, among other diseases. The DHFR …
fungal infection, malaria, leishmaniasis, and tuberculosis, among other diseases. The DHFR …
New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity
New series of thiazole and imidazo [2, 1-b] thiazole derivatives were synthesized and tested
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …
Application of N, N-Dimethylethanolamine as a One-Carbon Synthon for the Synthesis of Pyrrolo [1, 2-a] quinoxalines, Quinazolin-4-ones, and Benzo [4, 5] …
M Geng, M Huang, J Kuang, W Fang… - The Journal of …, 2022 - ACS Publications
The synthesis of N-heterocycles composes a significant part of synthetic chemistry. In this
report, a Cu (II)-catalyzed green and efficient synthesis of pyrrolo [1, 2-a] quinoxaline …
report, a Cu (II)-catalyzed green and efficient synthesis of pyrrolo [1, 2-a] quinoxaline …
Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2, 3, 4-trisubstituted thiophene derivatives
New series of thiophene derivatives were synthesized and evaluated for their in vivo anti-
inflammatory activity using carrageenan-induced paw edema model. The most active in vivo …
inflammatory activity using carrageenan-induced paw edema model. The most active in vivo …
Trimethoprim: An old antibacterial drug as a template to search for new targets. Synthesis, biological activity and molecular modeling study of novel trimethoprim …
A Wróbel, D Maliszewski, M Baradyn, D Drozdowska - Molecules, 2019 - mdpi.com
A new series of trimethoprim (TMP) analogs containing amide bonds (1–6) have been
synthesized. Molecular docking, as well as dihydrofolate reductase (DHFR) inhibition assay …
synthesized. Molecular docking, as well as dihydrofolate reductase (DHFR) inhibition assay …
Design and synthesis of new 4-(3, 4, 5-trimethoxyphenyl) thiazole–pyrimidine derivatives as potential antiproliferative agents
A new series of 3, 4, 5-trimethoxyphenyl thiazole pyrimidines has been synthesized and
biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with …
biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with …
Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3 H)-quinazolinones 3 N-substituted
M Pérez-Fehrmann, V Kesternich, A Puelles… - RSC …, 2022 - pubs.rsc.org
A novel series of 6-iodo-2-methylquinazolin-4-(3H)-one derivatives, 3a–n, were synthesized
and evaluated for their in vitro cytotoxic activity. Compounds 3a, 3b, 3d, 3e, and 3h showed …
and evaluated for their in vitro cytotoxic activity. Compounds 3a, 3b, 3d, 3e, and 3h showed …
Synthesis of Pyridine Clubbed Tetrahydrobenzo[b]thiophene Azo Dye Analogues Using the Gewald Reaction: Catalytic Optimization, Antibacterial, and Dye …
RV Aghara, MC Parmar, BY Patel - Russian Journal of General Chemistry, 2023 - Springer
A series of novel pyridine-bearing tetrahydrobenzo [b] thiophene-3-carbohydrazide mono
azo dyes was synthesized by combining the Gewald and azo dye approaches with basic …
azo dyes was synthesized by combining the Gewald and azo dye approaches with basic …
Novel naphthoquinone-1H-1, 2, 3-triazole hybrids: Design, synthesis and evaluation as inductors of ROS-mediated apoptosis in the MCF-7 cells
AS de Souza, DS Dias, RCB Ribeiro, DCS Costa… - Bioorganic & Medicinal …, 2024 - Elsevier
The search for novel anticancer drugs is essential to expand treatment options, overcome
drug resistance, reduce toxicity, promote innovation, and tackle the economic impact. The …
drug resistance, reduce toxicity, promote innovation, and tackle the economic impact. The …