Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …

A procedure for analyzing and classifying publicly available crystal structures has been
developed. It has been used to identify high-resolution protein− ligand complexes that can …

Thymidine phosphorylase (TP), also known as “platelet‐derived endothelial cell growth
factor”(PD‐ECGF), is an enzyme, which is upregulated in a wide variety of solid tumors …

Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery
since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first …

Current treatment modalities for cancer combine cytotoxic drugs against DNA and novel
targeted drugs affecting signal transduction pathways, which are required for growth …

Judging if a protein is able to bind orally available molecules with high affinity, ie if a protein
is druggable, is an important step in target assessment. In order to derive a structure-based …

A series of twelve pyrazol-3-one Schiffs base derivatives (5–17) were designed and
synthesized by microwave-assisted chemical synthesis. Their purity was confirmed by …

Human thymidine phosphorylase (HTP), also known as platelet-derived endothelial cell
growth factor (PD-ECGF), is overexpressed in certain solid tumors where it is linked to poor …

Publisher Summary The bioavailability of molecules exclusively screened through in vitro
assays can be low. In vivo administration is limited to the parenteral route, and their clinical …