Arginine, transsulfuration, and folic acid pathway metabolomics in chronic obstructive pulmonary disease: a systematic review and meta-analysis
A Zinellu, AA Mangoni - Cells, 2023 - mdpi.com
There is an increasing interest in biomarkers of nitric oxide dysregulation and oxidative
stress to guide management and identify new therapeutic targets in patients with chronic …
stress to guide management and identify new therapeutic targets in patients with chronic …
Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?
LES de Groot, TA Van Der Veen… - … of physiology-lung …, 2019 - journals.physiology.org
Oxidative stress is a common feature of obstructive airway diseases like asthma and chronic
obstructive pulmonary disease (COPD). Lung macrophages are key innate immune cells …
obstructive pulmonary disease (COPD). Lung macrophages are key innate immune cells …
l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway
C Ma, K Liao, J Wang, T Li, L Liu - Cell & Bioscience, 2023 - Springer
Backgrounds Chronic obstructive pulmonary disease (COPD) is a frequent and common
disease in clinical respiratory medicine and its mechanism is unclear. The purpose of this …
disease in clinical respiratory medicine and its mechanism is unclear. The purpose of this …
Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress
J Gao, T Lei, H Wang, K Luo, Y Wang, B Cui… - Particle and Fibre …, 2022 - Springer
Background Airborne fine particulate matter with aerodynamic diameter≤ 2.5 μm (PM2. 5)
pollution is associated with the prevalence of respiratory diseases, including asthma …
pollution is associated with the prevalence of respiratory diseases, including asthma …
Exhaled biomarkers for point-of-care diagnosis: Recent advances and new challenges in breathomics
H Kiss, Z Örlős, Á Gellért, Z Megyesfalvi, A Mikáczó… - Micromachines, 2023 - mdpi.com
Cancers, chronic diseases and respiratory infections are major causes of mortality and
present diagnostic and therapeutic challenges for health care. There is an unmet medical …
present diagnostic and therapeutic challenges for health care. There is an unmet medical …
Dysregulation of the endothelial nitric oxide pathway is associated with airway inflammation in COPD
Background Chronic obstructive pulmonary disease (COPD) is related to endothelial
dysfunction and the impaired generation of nitric oxide (NO) from L-arginine by the …
dysfunction and the impaired generation of nitric oxide (NO) from L-arginine by the …
Update on metabolomic findings in COPD patients
J Gea, CJ Enríquez-Rodríguez… - ERJ Open …, 2023 - Eur Respiratory Soc
COPD is a heterogeneous disorder that shows diverse clinical presentations (phenotypes
and “treatable traits”) and biological mechanisms (endotypes). This heterogeneity implies …
and “treatable traits”) and biological mechanisms (endotypes). This heterogeneity implies …
Dysregulation of the nitric oxide/Dimethylarginine pathway in hypoxic pulmonary vasoconstriction—molecular mechanisms and clinical significance
J Hannemann, R Böger - Frontiers in Medicine, 2022 - frontiersin.org
The pulmonary circulation responds to hypoxia with vasoconstriction, a mechanism that
helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary …
helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary …
Phenotyping of chronic obstructive pulmonary disease based on the integration of metabolomes and clinical characteristics
Apart from the refined management-oriented clinical stratification of chronic obstructive
pulmonary disease (COPD), the molecular pathologies behind this highly prevalent disease …
pulmonary disease (COPD), the molecular pathologies behind this highly prevalent disease …
A metabolomic severity score for airflow obstruction and emphysema
Chronic obstructive pulmonary disease (COPD) is a disease with marked metabolic
disturbance. Previous studies have shown the association between single metabolites and …
disturbance. Previous studies have shown the association between single metabolites and …