Helicobacter pylori, the causative agent of chronic superficial gastritis and duodenal ulcer
disease in humans, produces a unique cytotoxin (VacA) that induces cytoplasmic …

Several methods can be used to diagnose Helicobacter pylori infection. Invasive methods
include detection of the bacterium in gastric biopsy specimens by culture …

Helicobacter pylori toxin, VacA, damages the gastric epithelium by erosion and loosening of
tight junctions. Here we report that VacA also interferes with T cell activation by two different …

The mechanisms by which Helicobacter pylori releases its virulence factors are poorly
known. Active secretion has been proposed for some products, including a vacuolating toxin …

The vacuolating toxin VacA, a major determinant of Helicobacter pylori‐associated gastric
diseases, forms anion‐selective channels in artificial planar lipid bilayers. Here we show …

The effects of the vacuolating toxin (VacA) released by pathogenic strains of Helicobacter
pylori on several polarized epithelial monolayers were investigated. Trans-epithelial electric …

Background & Aims: Helicobacter pylori colonizes the human gastric mucosa of> 50% of the
world's population. Most of the patients have no overt clinical symptoms. However, the …

The Helicobacter pylori toxin VacA causes vacuolar degeneration in mammalian cell lines in
vitro and plays a key role in peptic ulcer disease. Two alleles, m1 and m2, of the mid-region …

Introduction: Helicobacter pylori infection is among the most common human infections and
the major risk factor for peptic disease and gastric cancer. Immunization with vaccines …

Helicobacter pylori induces cell death by apoptosis. However, the apoptosis-inducing factor
is still unknown. The virulence factor vacuolating cytotoxin A (VacA) is a potential candidate …