The generation of a peripheral T-cell pool is essential for normal immune system function.
CD4+ and CD8+ T cells are produced most efficiently in the thymus, which provides a …

The epithelial architecture of the thymus fosters growth, differentiation, and T cell receptor
repertoire selection of large numbers of immature T cells that continuously feed the mature …

The epithelial component of the thymic microenvironment is indispensable for the
generation of T lymphocytes. Although the heterogeneity of this epithelium is well …

Mice deficient for fibroblast growth factor (Fgf) R2-IIIb show a block in thymic growth after
embryonic day 12.5, a stage that just precedes its detection in thymic epithelial cells. Fgf7 …

The forkhead transcription factor Foxn1 is indispensable for thymus development, but the
mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly …

Abstract αβ T cells pass through a series of lymphoid tissue stromal microenvironments to
acquire self tolerance and functional competence. In the thymus, positive selection of the …

The thymus, a primary lymphoid organ, produces the T cells of the immune system.
Originating from the 3rd pharyngeal pouch during embryogenesis, this organ functions …

The thymus and parathyroid glands in mice develop from a thymus/parathyroid primordium
that forms from the endoderm of the third pharyngeal pouch. We investigated the molecular …

In the mature thymus, thymocyte maturation depends on interactions with different thymic
epithelial subtypes in a three-dimensional thymic architecture. However, the molecular …

Thymic organogenesis and T-cell lymphopoiesis are crucial interdependent processes that
establish a functional vertebrate immune system. The current understanding of vertebrate …