Adaptive reward-related decision making requires accurate prospective consideration of the
specific outcome of each option and its current desirability. These mental simulations are …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

To make an appropriate decision, one must anticipate potential future rewarding events,
even when they are not readily observable. These expectations are generated by using …

Natural anion channelrhodopsins (ACRs) discovered in the cryptophyte alga Guillardia theta
generate large hyperpolarizing currents at membrane potentials above the Nernst …

We recently developed a rat model of relapse to drug seeking after food choice-induced
voluntary abstinence. Here, we used this model to study the role of the orbitofrontal cortex …

Cocaine addiction is a devastating public health epidemic that continues to grow. Studies
focused on identifying biological factors influencing cocaine craving and relapse …

Adaptive reward-related decision making often requires accurate and detailed
representation of potential available rewards. Environmental reward-predictive stimuli can …

The prefrontal cortex (PFC) is usually defined as the frontal cortical area receiving a
mediodorsal thalamic (MD) innervation. Certain areas in the medial wall of the rat frontal …

Addiction is a chronic relapsing disorder, in that most addicted individuals who choose to
quit taking drugs fail to maintain abstinence in the long-term. Relapse is especially likely …

Drug addiction is a chronic relapsing disorder, and a significant amount of research has
been devoted to understand the factors that contribute to the development, loss of control …