Streptozotocin‐induced diabetes models: Pathophysiological mechanisms and fetal outcomes

DC Damasceno, AO Netto, IL Iessi… - BioMed research …, 2014 - Wiley Online Library
Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic
disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present …

Paternal low-dose benzo (a) pyrene exposure in rats impairs sexual development and fertility of the paternal lineage in F2 generation: A transgenerational study

BC Jorge, J Stein, ACC Reis, JN Bueno… - Toxicology, 2023 - Elsevier
Abstract The field of Paternal Origins of Health and Disease (POHaD) is highly relevant but
remains under-explored. The F2 generation from males indirectly exposed (F1-via germ …

Experimental diabetes impairs maternal reproductive performance in pregnant Wistar rats and their offspring

L Bequer, T Gómez, JL Molina, A Álvarez… - Systems biology in …, 2018 - Taylor & Francis
The aim of this study was to determine the effect of mild hyperglycemia on metabolism
during pregnancy, the maternal reproductive performance, and the characteristics of the …

[HTML][HTML] Exposure of pregnant rats to stress and/or sertraline: Side effects on maternal health and neurobehavioral development of male offspring

AFQ Lozano, MS Moura, BM Tavares, WDG Kempinas - Life Sciences, 2021 - Elsevier
Aims Sertraline (SE) is one of the most prescribed medications for treating gestational
depression, anxiety and stress. However, little is known about its effects on nervous-system …

[HTML][HTML] Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats

MM de Almeida, SCPD Luquetti, CM Sabarense… - Lipids in Health and …, 2014 - Springer
Background Evidence from in vitro and animal studies indicates that conjugated linoleic acid
(CLA) possesses anti-diabetic properties, which appear to be attributed to cis-9, trans-11 …

Effect of paracetamol treatment on maternal care and reproductive outcomes in female rat offspring

JF Aleixo, MRF Pereira, BG Montagnini… - Reproduction …, 2021 - CSIRO Publishing
Paracetamol (PAR) is one of the most commonly used drugs by pregnant women because it
is considered safe for the mother and fetus. However, PAR is transferred into breast milk and …

[HTML][HTML] Protein restriction during lactation causes transgenerational metabolic dysfunction in adult rat offspring

R Vargas, IP Martins, CCI Matiusso… - Frontiers in …, 2023 - frontiersin.org
Introduction Protein restriction during lactation can induce metabolic dysfunctions and has a
huge impact on the offspring's phenotype later in its life. We tested whether the effects of a …

Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats

ALO Carvalho, BG Ferri, FAL de Sousa… - International Journal of …, 2016 - Elsevier
Several studies have investigated the effects of artificial litter size adjustment on offspring
development. Social play behavior is important for neurobehavioral development and is …

Maternal diabetes affects rat offspring retinal structure and function: Sex-specific vulnerabilities at infancy

AM Realinho, R Boia, B Paiva, RG Correia, R Gaspar… - Life Sciences, 2023 - Elsevier
Aims Maternal diabetes negatively impacts the offspring's brain, but little is known about its
effects on the retina, which is also part of the central nervous system. We hypothesized that …

Maternal Hyperglycemia Induces Autonomic Dysfunction and Heart Failure in Older Adult Offspring

OA da Silva, GP Duarte, S Lahlou - Experimental and Clinical …, 2023 - thieme-connect.com
Aims Offspring exposed to an adverse fetal environment, such as gestational diabetes, may
manifest increased susceptibility to several chronic diseases later in life. In the present …