Manipulating the destiny of wild populations using CRISPR

R Raban, JM Marshall, BA Hay… - Annual review of …, 2023 - annualreviews.org
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Advances and challenges in synthetic biology for mosquito control

SC Weng, RA Masri, OS Akbari - Trends in parasitology, 2024 - cell.com
Mosquito-borne illnesses represent a significant global health peril, resulting in
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …

Loss-of-function in testis-specific serine/threonine protein kinase triggers male infertility in an invasive moth

Z Wei, Y Wang, K Zheng, Z Wang, R Liu… - Communications …, 2024 - nature.com
Genetic biocontrol technologies present promising and eco-friendly strategies for the
management of pest and insect-transmitted diseases. Although considerable advancements …

Targeting sex determination to suppress mosquito populations

M Li, NP Kandul, R Sun, T Yang, ED Benetta… - Elife, 2024 - elifesciences.org
Each year, hundreds of millions of people are infected with arboviruses such as dengue,
yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious …

Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth Plutella xylostella

X Xu, T Harvey-Samuel, HA Siddiqui, JXD Ang… - The CRISPR …, 2022 - liebertpub.com
Promising to provide powerful genetic control tools, gene drives have been constructed in
multiple dipteran insects, yeast, and mice for the purposes of population elimination or …

Eliminating malaria vectors with precision-guided sterile males

RA Apte, AL Smidler, JJ Pai, ML Chow, S Chen… - Proceedings of the …, 2024 - pnas.org
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However, existing vector control …

[HTML][HTML] A history of the genetic and molecular identification of genes and their functions controlling insect sex determination

G Saccone - Insect Biochemistry and Molecular Biology, 2022 - Elsevier
The genetics of the sex determination regulatory cascade in Drosophila melanogaster has a
fascinating history, interlinked with the foundation of the Genetics discipline itself. The …

[HTML][HTML] CRISPR-based genetic control strategies for insect pests

YAN Ying, RA Aumann, I Häcker… - Journal of Integrative …, 2023 - Elsevier
Genetic control strategies such as the sterile insect technique have successfully fought
insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic …

Next-generation CRISPR gene-drive systems using Cas12a nuclease

S Sanz Juste, EM Okamoto, C Nguyen, X Feng… - Nature …, 2023 - nature.com
One method for reducing the impact of vector-borne diseases is through the use of CRISPR-
based gene drives, which manipulate insect populations due to their ability to rapidly …

Manipulating insect sex determination pathways for genetic pest management: opportunities and challenges

A Siddall, T Harvey-Samuel, T Chapman… - … in Bioengineering and …, 2022 - frontiersin.org
Sex determination pathways in insects are generally characterised by an upstream primary
signal, which is highly variable across species, and that regulates the splicing of a suite of …