Manipulating the destiny of wild populations using CRISPR
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
Advances and challenges in synthetic biology for mosquito control
Mosquito-borne illnesses represent a significant global health peril, resulting in
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …
Loss-of-function in testis-specific serine/threonine protein kinase triggers male infertility in an invasive moth
Z Wei, Y Wang, K Zheng, Z Wang, R Liu… - Communications …, 2024 - nature.com
Genetic biocontrol technologies present promising and eco-friendly strategies for the
management of pest and insect-transmitted diseases. Although considerable advancements …
management of pest and insect-transmitted diseases. Although considerable advancements …
Targeting sex determination to suppress mosquito populations
Each year, hundreds of millions of people are infected with arboviruses such as dengue,
yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious …
yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious …
Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth Plutella xylostella
Promising to provide powerful genetic control tools, gene drives have been constructed in
multiple dipteran insects, yeast, and mice for the purposes of population elimination or …
multiple dipteran insects, yeast, and mice for the purposes of population elimination or …
Eliminating malaria vectors with precision-guided sterile males
RA Apte, AL Smidler, JJ Pai, ML Chow, S Chen… - Proceedings of the …, 2024 - pnas.org
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However, existing vector control …
considered essential to curtail malaria transmission. However, existing vector control …
[HTML][HTML] A history of the genetic and molecular identification of genes and their functions controlling insect sex determination
G Saccone - Insect Biochemistry and Molecular Biology, 2022 - Elsevier
The genetics of the sex determination regulatory cascade in Drosophila melanogaster has a
fascinating history, interlinked with the foundation of the Genetics discipline itself. The …
fascinating history, interlinked with the foundation of the Genetics discipline itself. The …
[HTML][HTML] CRISPR-based genetic control strategies for insect pests
YAN Ying, RA Aumann, I Häcker… - Journal of Integrative …, 2023 - Elsevier
Genetic control strategies such as the sterile insect technique have successfully fought
insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic …
insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic …
Next-generation CRISPR gene-drive systems using Cas12a nuclease
S Sanz Juste, EM Okamoto, C Nguyen, X Feng… - Nature …, 2023 - nature.com
One method for reducing the impact of vector-borne diseases is through the use of CRISPR-
based gene drives, which manipulate insect populations due to their ability to rapidly …
based gene drives, which manipulate insect populations due to their ability to rapidly …
Manipulating insect sex determination pathways for genetic pest management: opportunities and challenges
A Siddall, T Harvey-Samuel, T Chapman… - … in Bioengineering and …, 2022 - frontiersin.org
Sex determination pathways in insects are generally characterised by an upstream primary
signal, which is highly variable across species, and that regulates the splicing of a suite of …
signal, which is highly variable across species, and that regulates the splicing of a suite of …