The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

INTRODUCTION Obtaining multiplexed molecular readouts from large numbers of single
cells in situ is an important technological goal to facilitate scientific discoveries in basic and …

Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …

There are many pathways of endocytosis at the cell surface that apparently operate at the
same time. With the advent of new molecular genetic and imaging tools, an understanding of …

Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …

Cetuximab is a monoclonal antibody that is effective in the treatment of metastatic colorectal
cancer (mCRC). Cetuximab blocks epidermal growth factor receptor (EGFR)-ligand …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …