The OMICs cascade describes the hierarchical flow of information through biological
systems. The epigenome sits at the apex of the cascade, thereby regulating the RNA and …

Adverse drug reactions (ADRs) are major clinical problems, particularly in special
populations such as pediatric patients. Indeed, ADRs may be caused by a plethora of …

Background Human induced pluripotent stem cells (iPSCs) are a promising tool to
investigate pathogenic mechanisms underlying human genetic conditions, such as …

Hyperoxia-induced lung injury occurs in neonates on oxygen support due to premature birth,
often leading to the development of bronchopulmonary dysplasia. Current treatment options …

Background Metabolomics is the systemic study of the unique fingerprints of metabolites
involved in cellular processes and biochemical reactions. The metabolomic approach is …

Somatic cells such as skin fibroblasts, umbilical cord blood, peripheral blood, urinary
epithelial cells, etc., are transformed into induced pluripotent stem cells (iPSCs) by …

Reprogramming cells to gain pluripotency or a different lineage has been a breakthrough
enabling disease modeling, drug discovery, toxicity testing, drug repurposing for new …

Abstract Arboleda-Tham Syndrome (ARTHS, OMIM# 616268) is a rare neurodevelopmental
disorder caused by de novo mutations in KAT6A. Individuals with ARTHS typically exhibit …

儿童疾病的最佳诊断和治疗依赖于对病理生理学更充分的认识, 而诱导多能干细胞(induced
pluripotent stem cells, iPSCs) 的出现则为儿童疾病的研究和治疗提供了新的策略. iPSCs …

Zusammenfassung Die Umprogrammierung von Zellen, um Pluripotenz oder eine andere
Abstammungslinie zu erlangen, ist ein Durchbruch, der die Modellierung von Krankheiten …