Infantile spasms: an update on pre-clinical models and EEG mechanisms

R Janicot, LR Shao, CE Stafstrom - Children, 2020 - mdpi.com
Infantile spasms (IS) is an epileptic encephalopathy with unique clinical and electrographic
features, which affects children in the middle of the first year of life. The pathophysiology of …

Treatment of infantile spasms: why do we know so little?

N Specchio, N Pietrafusa, A Ferretti… - Expert review of …, 2020 - Taylor & Francis
Introduction Infantile spasm (IS) is an epileptic syndrome with typical onset within the first 2
years of life. This condition might be caused by several etiologies. IS is associated with …

Signal processing and computational modeling for interpretation of SEEG-recorded interictal epileptiform discharges in epileptogenic and non-epileptogenic zones

E Köksal-Ersöz, R Lazazzera, M Yochum… - Journal of Neural …, 2022 - iopscience.iop.org
Objective. In partial epilepsies, interictal epileptiform discharges (IEDs) are paroxysmal
events observed in epileptogenic zone (EZ) and non-epileptogenic zone (NEZ). IEDs' …

[HTML][HTML] Multiscale neuro-inspired models for interpretation of EEG signals in patients with epilepsy

F Wendling, E Koksal-Ersoz, M Al-Harrach… - Clinical …, 2024 - Elsevier
Objective The aim is to gain insight into the pathophysiological mechanisms underlying
interictal epileptiform discharges observed in electroencephalographic (EEG) and stereo …

Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms

RD Traub, F Moeller, R Rosch, T Baldeweg… - Reviews in the …, 2020 - degruyter.com
Infantile spasms (IS) and seizures with focal onset have different clinical expressions, even
when electroencephalography (EEG) associated with IS has some degree of focality. Oddly …

Complexities of Cortex and the Need for Detailed Models

R Traub, A Draguhn - Brain Leitmotifs: The Structure and Activity Patterns …, 2024 - Springer
In the next chapters, we shall consider mammalian cortical structures, including the
neocortex, piriform (olfactory) cortex, entorhinal cortex, and hippocampus: their neurons …

Brain Leitmotifs

R Traub, A Draguhn - Springer
A major problem of Neuroscience concerns the relationship between the activities of one or
more neurons and “something else”: something internal to the animal, such as actions …