Microvascular NADPH oxidase in health and disease

Y Li, PJ Pagano - Free Radical Biology and Medicine, 2017 - Elsevier
The systemic and cerebral microcirculation contribute critically to regulation of local and
global blood flow and perfusion pressure. Microvascular dysfunction, commonly seen in …

Amelioration of ethanol-induced gastric ulcer in rats by quercetin: implication of Nrf2/HO1 and HMGB1/TLR4/NF-κB pathways

SGE Shams, RG Eissa - Heliyon, 2022 - cell.com
Gastric ulcer is a serious medical condition that can be developed due to an imbalance in
the protective and destructive factors of the gastric system. Available therapies do not …

Pharmacological effects and toxicogenetic impacts of omeprazole: genomic instability and cancer

MFCJ Paz, MVOB de Alencar… - Oxidative medicine …, 2020 - Wiley Online Library
Omeprazole (OME) is commonly used to treat gastrointestinal disorders. However, long‐
term use of OME can increase the risk of gastric cancer. We aimed to characterize the …

Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima

O Guzmán-Gómez, RV García-Rodríguez… - Nutrients, 2018 - mdpi.com
Phycobiliproteins of Arthrospira (Spirulina) maxima have attracted attention because of their
potential therapeutic antioxidant properties. The aim of this study was to assess the possible …

Formulation, optimization and characterization of allantoin-loaded chitosan nanoparticles to alleviate ethanol-induced gastric ulcer: in-vitro and in-vivo studies

RM Aman, RA Zaghloul, MS El-Dahhan - Scientific reports, 2021 - nature.com
Allantoin (ALL) is a phytochemical possessing an impressive array of biological activities.
Nonetheless, developing a nanostructured delivery system targeted to augment the gastric …

The implication of the crosstalk of Nrf2 with NOXs, and HMGB1 in ethanol-induced gastric ulcer: Potential protective effect is afforded by Raspberry Ketone

AM Badr, NF El-Orabi, RA Ali - PloS one, 2019 - journals.plos.org
Ethanol consumption is one of the common causative agents implicated in gastric ulcer
development. Oxidative stress plays a major role in the induction and development of gastric …

Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling …

RM Salama, RH Ahmed, AA Farid… - International …, 2023 - Elsevier
Alcohol abuse may lead to the development of gastric mucosal lesions. Dapagliflozin
(DAPA), a sodium-glucose cotransporter-2 inhibitor, is clinically used to treat type 2 diabetes …

Combined apocynin and carvedilol protect against cadmium-induced testicular damage via modulation of inflammatory response and redox-sensitive pathways

AG Bakr, EHM Hassanein, FEM Ali, EAM El-Shoura - Life Sciences, 2022 - Elsevier
Testicular damage is considered a severe complication of cadmium (Cd) exposure which is
associated with tissue oxidative stress damage, inflammation, and apoptosis. The present …

In vivo and In silico evidence of the protective properties of carvacrol against experimentally-induced gastric ulcer: Implication of antioxidant, anti-inflammatory, and …

AM Badr, NF El-Orabi, YF Mahran, AM Badr… - Chemico-Biological …, 2023 - Elsevier
Gastric ulcer is a serious disease that affects millions of individuals worldwide. Alcohol
consumption is a major contributor to the disease pathogenesis and ethanol-induced ulcer …

Novel chitosan oligosaccharide-based nanoparticles for gastric mucosal administration of the phytochemical “apocynin”

HM Anter, II Abu Hashim, W Awadin… - International Journal of …, 2019 - Taylor & Francis
Background: Apocynin (APO) is a bioactive phytochemical with prominent anti-inflammatory
and anti-oxidant activities. Designing a nano-delivery system targeted to potentiate the …