Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Cell-based medicine has made great advances in clinical diagnosis and therapy for various
refractory diseases, inducing a growing demand for cell preservation as support technology …

For the treatment of systemic hypertension, pharmacological intervention in nitric oxide-
cyclic guanosine monophosphate signaling is a well-explored but unexploited option. In this …

Hypothermic preservation (HP) is highly desired for the maintenance of the viability of living
cell specimens, eg rare cells in whole-blood samples or therapeutic cells, in an unfrozen …

There is an ever-growing need of human tissues and organs for transplantation. However,
the availability of such tissues and organs is insufficient by a large margin, which is a huge …

Background Alzheimer's disease (AD) is the most prevalent neurodegenerative disease
worldwide and remains without effective cure. Increasing evidence is supporting the …

Aims/hypothesis The immunomodulatory capacity of adipose tissue-derived stromal cells
(ASCs) is relevant for next-generation cell therapies that aim to reverse tissue dysfunction …

Defective cellular metabolism, impaired mitochondrial function, and increased cell death are
major problems that adversely affect donor tissues during hypothermic preservation prior to …

Mesenchymal stem cells have generated a great deal of interest due to their potential use in
regenerative medicine and tissue engineering. Examples illustrating their therapeutic value …

Cooling at 4° C is routinely used to lower metabolism and preserve cell and tissue integrity
in laboratory and clinical settings, including organ transplantation. However, cooling and …