Physiological role of bile acids modified by the gut microbiome

Y Kiriyama, H Nochi - Microorganisms, 2021 - mdpi.com
Bile acids (BAs) are produced from cholesterol in the liver and are termed primary BAs.
Primary BAs are conjugated with glycine and taurine in the liver and then released into the …

Bile acids as inflammatory mediators and modulators of intestinal permeability

N Calzadilla, SM Comiskey, PK Dudeja… - Frontiers in …, 2022 - frontiersin.org
Bile acids are critical for the digestion and absorption of lipids and fat-soluble vitamins;
however, evidence continues to emerge supporting additional roles for bile acids as …

[HTML][HTML] Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism

X Sun, Y Zhang, G Cheng, T Zhu, Z Zhang… - Biomedicine & …, 2023 - Elsevier
Ulcerative colitis (UC) has been confirmed as a disease with a high incidence and low cure
rate worldwide. In severe cases, UC can develop into colon cancer. Modern research has …

Amelioration of colitis by a gut bacterial consortium producing anti-inflammatory secondary bile acids

C Zhou, Y Wang, C Li, Z Xie, L Dai - Microbiology Spectrum, 2023 - Am Soc Microbiol
ABSTRACT The Integrative Human Microbiome Project and other cohort studies have
indicated that inflammatory bowel disease is accompanied by dysbiosis of gut microbiota …

Gut Microbiota: The Potential Key Target of TCM's Therapeutic Effect of Treating Different Diseases Using the Same Method—UC and T2DM as Examples

B Zhang, K Liu, H Yang, Z Jin, Q Ding… - Frontiers in Cellular and …, 2022 - frontiersin.org
Traditional Chinese herbal medicine often exerts the therapeutic effect of “treating different
diseases with the same method” in clinical practice; in other words, it is a kind of herbal …

Transcriptome and targeted metabolome analysis provide insights into bile acids' new roles and mechanisms on fat deposition and meat quality in lamb

B Zhang, Z Sun, Z Yu, H Li, H Luo, B Wang - Food Research International, 2022 - Elsevier
Higher quality lamb carcasses with more muscle and less fat are crucial for consumer
preference and healthy eating. This study evaluated bile acids' functional roles and …

Multifaceted effects of subchronic exposure to chlorfenapyr in mice: implications from serum metabolomics, hepatic oxidative stress, and intestinal homeostasis

Y Xiong, X Ma, B He, J Zhi, X Liu, P Wang… - Journal of Agricultural …, 2024 - ACS Publications
As chlorfenapyr is a commonly used insecticide in agriculture, the health risks of subchronic
exposure to chlorfenapyr remained unclear. This study aimed to extensively probe the …

Paeonol ameliorates ulcerative colitis in mice by modulating the gut microbiota and metabolites

J Zheng, H Li, P Zhang, S Yue, B Zhai, J Zou, J Cheng… - Metabolites, 2022 - mdpi.com
Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the gastrointestinal
tract. Recent studies demonstrate that the phenolic tannin paeonol (Pae) attenuates UC in …

The role of gut microbiota-bile acids axis in the progression of non-alcoholic fatty liver disease

Y Ni, M Lu, Y Xu, Q Wang, X Gu, Y Li… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), an emerging global health problem affecting 25–
30% of the total population, refers to excessive lipid accumulation in the liver accompanied …

[HTML][HTML] Molecular signalling during cross talk between gut brain axis regulation and progression of irritable bowel syndrome: A comprehensive review

SV Singh, R Ganguly, K Jaiswal, AK Yadav… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Irritable bowel syndrome (IBS) is a chronic functional disorder which alters gastrointestinal
(GI) functions, thus leading to compromised health status. Pathophysiology of IBS is not fully …