The term “SOS response” was first coined by Radman in 1974, in an intellectual effort to put
together the data suggestive of a concerted gene expression program in cells undergoing …

Pseudomonas putida is a fast-growing bacterium found mostly in temperate soil and water
habitats. The metabolic versatility of P. putida makes this organism attractive for …

To better understand adaptation to harsh conditions encountered in hot arid deserts, we
report the first complete genome sequence and proteome analysis of a bacterium …

In Mycobacterium tuberculosis (Mtb), damage-induced mutagenesis is dependent on the C-
family DNA polymerase, DnaE2. Included with dnaE2 in the Mtb SOS regulon is a putative …

The analysis of∼ 2000 bacterial genomes revealed that they all, without a single exception,
encode one or more DNA polymerase III α-subunit (PolIIIα) homologs. Classified into C …

In some enterobacterial pathogens, but not in Escherichia coli, loss-of-function mutations are
a common route to clinically relevant β-lactam antibiotic resistance. We previously …

Antibiotics exert selective pressures on clinically relevant antibiotic resistance. It is critical to
understand how antibiotic resistance evolves in environmental microbes exposed to …

Deinococcus bacteria are extremely resistant to radiation and able to repair a shattered
genome in an essentially error-free manner after exposure to high doses of radiation or …

In a growth-restricting environment, mutants arise that are able to take over bacterial
populations by a process known as adaptive mutation or stationary-phase mutation. This …

Faithful replication and maintenance of the genome are essential to the ability of any
organism to survive and propagate. For an obligate pathogen such as Mycobacterium …