In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that
lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the …

Ferroptosis is a newly characterized form of iron-dependent non-apoptotic cell death, which
is closely associated with cancer progression. However, the functions and mechanisms in …

Transcriptionally active and inactive chromatin domains tend to segregate into separate sub-
nuclear compartments to maintain stable expression patterns. However, here we uncovered …

Background The nuclear envelope not only serves as a physical barrier separating nuclear
content from the cytoplasm but also plays critical roles in modulating the three-dimensional …

WNT signaling activates MYC expression in cancer cells. Here we report that this involves
an oncogenic super-enhancer-mediated tethering of active MYC alleles to nuclear pores to …

Germ cells are unique in engendering totipotency, yet the mechanisms underlying this
capacity remain elusive. Here, we perform comprehensive and in‐depth nucleome analysis …

The nucleus is a highly organized membrane-bound organelle that envelops and regulates
multiple aspects of the genome. The nuclear membrane is composed of a complex lipid …

Purpose of review In this review, we explore the chromatin-related consequences of
laminopathy-linked mutations through the lens of mechanotransduction. Recent findings …

Lamina‐associated domains are large regions of heterochromatin positioned at the nuclear
periphery. These domains have been implicated in gene repression, especially in the …