In health, the glucose concentration of airway surface liquid (ASL) is 0.4 mM, about 12 times
lower than the blood glucose concentration. Airway glucose homeostasis comprises a set of …

Biological sex differences exist for many airway diseases in which females have either
worse or better health outcomes. Inflammatory airway diseases such as cystic fibrosis (CF) …

Background Effective removal of pathogenic bacteria is key to improving the prognosis of
sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate …

Neutrophils can function and survive in injured and infected tissues, where oxygen and
metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13 …

Sarcoidosis is a disease of unknown etiology in which granulomas form throughout the body
and is typically treated with glucocorticoids, but there are no approved steroid-sparing …

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …

Fine control of macrophage activation is needed to prevent inflammatory disease,
particularly at barrier sites such as the lungs. However, the dominant mechanisms that …

Cystic fibrosis-related diabetes (CFRD) patients suffer from accelerated rates of pulmonary
decline compared to cystic fibrosis (CF) patients with normal glucose tolerance (NGT) …

SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that
reached pandemic proportions among the human population within months. The reasons for …

In the upper respiratory epithelium, bitter and sweet taste receptors present in solitary
chemosensory cells influence antimicrobial innate immune defense responses. Whereas …