Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway

Z Heli, C Hongyu, B Dapeng, T Yee Shin, Z Yejun… - Frontiers in …, 2022 - frontiersin.org
γ-aminobutyric acid (GABA) is a non-protein amino acid which naturally and widely occurs in
animals, plants, and microorganisms. As the chief inhibitory neurotransmitter in the central …

Deep-brain optical recording of neural dynamics during behavior

ZC Zhou, A Gordon-Fennell, SC Piantadosi, N Ji… - Neuron, 2023 - cell.com
In vivo fluorescence recording techniques have produced landmark discoveries in
neuroscience, providing insight into how single cell and circuit-level computations mediate …

Cellular and circuit architecture of the lateral septum for reward processing

G Chen, S Lai, S Jiang, F Li, K Sun, X Wu, K Zhou… - Neuron, 2024 - cell.com
The lateral septum (LS) is composed of heterogeneous cell types that are important for
various motivated behaviors. However, the transcriptional profiles, spatial arrangement …

A putative loop connection between VTA dopamine neurons and nucleus accumbens encodes positive valence to compensate for hunger

X Cui, Q Tong, H Xu, C Xie, L Xiao - Progress in Neurobiology, 2023 - Elsevier
Dopamine (DA) signal play pivotal roles in regulating motivated behaviors, including feeding
behavior, but the role of midbrain DA neurons in modulating food intake and neural circuitry …

An open-source platform for head-fixed operant and consummatory behavior

A Gordon-Fennell, JM Barbakh, MKT Utley, S Singh… - Elife, 2023 - elifesciences.org
Head-fixed behavioral experiments in rodents permit unparalleled experimental control,
precise measurement of behavior, and concurrent modulation and measurement of neural …

Lateral septum inputs to nucleus accumbens mediates stress induced suppression of natural reward seeking

K Zhang, YC Guo, XD Wang, YJ Zhu, BX Pan… - Pharmacological …, 2022 - Elsevier
Stress alters the level of reward evaluation and seeking. However, the neural circuitry
mechanisms underlying stress induced effects on natural reward seeking remain unclear …

[HTML][HTML] Increased meal-induced neurotensin response predicts successful maintenance of weight loss–Data from a randomized controlled trial

AO Brethvad, HL Zakariassen, J Holt, JR Lundgren… - Metabolism, 2023 - Elsevier
Background The gut derived anorexigenic hormone neurotensin (NT) is upregulated after
bariatric surgery which may contribute to the sustained weight loss. In contrast, diet-induced …

A thalamic nucleus reuniens–lateral septum–lateral hypothalamus circuit for comorbid anxiety–like behaviors in chronic itch

SS Guo, Y Gong, TT Zhang, XY Su, YJ Wu, YX Yan… - Science …, 2024 - science.org
Chronic itch often clinically coexists with anxiety symptoms, creating a vicious cycle of itch-
anxiety comorbidities that are difficult to treat. However, the neuronal circuit mechanisms …

Spatial transcriptomic analysis of the mouse brain following chronic social defeat stress

T Wang, Z Song, X Zhao, Y Wu, L Wu… - …, 2023 - Wiley Online Library
Depression is a highly prevalent and disabling mental disorder, involving numerous genetic
changes that are associated with abnormal functions in multiple regions of the brain …

Neuropeptides modulate feeding via the dopamine reward pathway

R Jin, S Sun, Y Hu, H Zhang, X Sun - Neurochemical Research, 2023 - Springer
Dopamine (DA) is a catecholamine neurotransmitter widely distributed in the central nervous
system. It participates in various physiological functions, such as feeding, anxiety, fear …